With the leisure of time, kinetic proofreading can still perform reliable ligand discrimination

Kinetic proofreading is a canonical scheme believed to be
responsible for the high ligand discrimination capacity of
many biochemical processes. In a recent PNAS publication,
Kirby and Zilman studied kinetic proofreading for receptor
signaling and argued that when stochasticity is taken into
account, having more proofreading steps does not generally
improve the discrimination of different receptor-binding lig-
ands based on counts of signaling molecules produced (1).