Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor

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DOI http://dx.doi.org/10.1039/d3cc00332a
Reference S.W. van Dongen, I. Baglai, M. Leeman, R.M. Kellogg, B. Kaptein and W.L. Noorduin, Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor, Chem. Commun. 59, (26), 3838-3841 (2023)
Group Self-Organizing Matter

We demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition. We establish that the combination of slow growth and fast dissolution of crystals is ideal for rapid deracemization, which we achieve by repurposing a Soxhlet apparatus to realize the slow removal and fast re-addition of solvent autonomously.