Picturing protein disaggregation

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Publication date
DOI http://dx.doi.org/10.1038/s41589-022-00977-w
Reference S.J. Tans, Picturing protein disaggregation, Nature Chem. Biol. 18, 240-241 (2022)
Group Biophysics

Just how chaperones clear protein aggregates is a notoriously impenetrable problem. A new study now shows how single-molecule movies of Hsp104 and Hsp70 chaperones acting on amyloid fibers are the key to revealing their underlying cooperation in time and space.