Multiplexing biochemical signals

Back to all publications

Publication date
DOI http://dx.doi.org/10.1103/PhysRevLett.107.048101
Reference W.H. de Ronde, F. Tostevin and P.R. ten Wolde, Multiplexing biochemical signals, Phys.Rev.Lett. 107, (4) (2011)
Group Biochemical Networks

In this Letter we show that living cells can multiplex biochemical signals, i.e., transmit multiple signals through the same signaling pathway simultaneously, and yet respond to them very specifically. We demonstrate how two binary input signals can be encoded in the concentration of a common signaling protein, which is then decoded such that each of the two output signals provides reliable information about one corresponding input. Under biologically relevant conditions the network can reach the maximum amount of information that can be transmitted, which is 2 bits.