Impact of crowders on the morphology of bacterial chromosomes

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Reference A. Kumar, P. Swain, B.M. Mulder and D. Chaudhuri, Impact of crowders on the morphology of bacterial chromosomes, EPL (Europhysics Letters) 128, 6: 68003: 1-7 (2020)
Group Theory of Biomolecular Matter

Inspired by recent experiments on the effects of cytosolic crowders on the organization of bacterial chromosomes, we consider a “feather-boa” type model chromosome in the presence of non-additive crowders, encapsulated within a cylindrical cell. We observe spontaneous emergence of complementary helicity of the confined polymer and crowders. This feature is reproduced within a simplified effective model of the chromosome. This latter model further establishes the occurrence of longitudinal and transverse spatial segregation transitions between the chromosome and crowders upon increasing the crowder size.