Flexibility in noisy cell-to-cell information dynamics

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DOI http://dx.doi.org/10.1103/physrevresearch.6.043252
Reference I. Qunbar, M. Vennettilli and A. Erez, Flexibility in noisy cell-to-cell information dynamics, Phys. Rev. Research 6, (4), 043252: 1-8 (2024)
Group Biochemical Networks

The exchange of molecules allows cells to exchange information. How robust is the information to changes in cell parameters? We use a mapping between the stochastic dynamics of two cells sharing a stimulatory molecule and parameters akin to an extension of Landau’s equilibrium phase transition theory. We show that different single-cell dynamics lead to the same dynamical response—a flexibility that cells can use. The companion equilibrium Landau model behaves similarly, thereby describing the dynamics of information in a broad class of models with coupled order parameters.