Canalization of C. elegans Vulva Induction against Anatomical Variability

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DOI http://dx.doi.org/10.1016/j.cels.2017.01.009
Reference G. Huelsz-Prince and J.S. Zon, Canalization of C. elegans Vulva Induction against Anatomical Variability, Cell Systems 4, 219-230 (2017)
Group Quantitative Developmental Biology

It is not understood how development occurs with astounding reproducibility despite variability on the cellular level. We show how a feedback mechanism involving cell signaling and migration generates an invariant cell fate pattern in C.elegans vulva development, even though anatomical variability causes strong initial variation in cell fate induction.