A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

Back to all publications

Publication date
DOI http://dx.doi.org/10.1039/C8OB02660B
Reference I. Baglai, M. Leeman, R.M. Kellogg and W.L. Noorduin, A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam, Org. Biomol. Chem, (2018)
Group Self-Organizing Matter

A simple asymmetric synthesis route to the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.