Tissue analysis with high resolution imaging mass spectrometry

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DOI http://dx.doi.org/10.1007/978-1-59745-493-3_18
Reference A.F.M. Altelaar and R.M.A. Heeren: Tissue analysis with high resolution imaging mass spectrometry In: Mass spectrometry of proteins and peptides : Methods and protocols /ed. M.S. Lipton and Ljiljana Pasa-Tolic, Humana Press, 2009. - pp. 295-308

Molecular mass spectrometric images of tissue sections facilitate precise location of biomolecules, drugs, their metabolites and the biomolecular aberrations they target. Technological developments are rapidly expanding the capabilities of imaging mass spectrometers. Speed, resolution, sensitivity, and sample preparation protocols are no longer limiting factors in its application.