Seeing and sensing chaperone-mediated protein folding acceleration

Date posted September 14, 2017
Type PhD positions

Chaperones are central to protein folding, maintenance, and disease, but how and when they affect protein chains has remained difficult to study directly. Recently it has become possible to detect protein conformational changes mediated by chaperones, as we have shown at the single-molecule level using optical tweezers for SecB, Trigger Factor, and Hsp70 (Science 2007, Nature 2013, Nature 2016). A recent extension by integrating single-molecule fluorescence, now allows us to visualize the composition of dynamic chaperone-client complexes, and their effects on client states. In this project, we will apply this approach to determine the mechanisms underlying chaperone foldase action, for a range of other intriguing chaperone systems and protein clients.

About the group



We are looking for an outstanding experimental physicist or chemist with an interest in single-molecule biophysics, and a strong drive to excel in a competitive international environment. As a postdoc position you must meet the requirements for a doctors-degree. You will need to meet the requirements for an MSc-degree, to ensure eligibility for a Dutch PhD examination.

Terms of employment

The position is intended as full-time (40 hours / week, 12 months / year) appointment in the service of the Netherlands Foundation of Scientific Research Institutes (NWO-I) for the duration of four years. After successful completion of the PhD research a PhD degree will be granted at Delft  University of Technology. Several courses are offered, specially developed for PhD-students. AMOLF assists any new PhD-student with housing and visa applications and compensates their transport costs and furnishing expenses.

Contact info

Prof.dr. ir Sander Tans
Group leader Biophysics
Phone: +31 (0)20-754 7100

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